Venture City Punk
We'll start by creating Venture City, deciding what some of the main factions, faces, issues and threats are for our fair city. There are a few elements of the setting as written, like Aegis Security and Mitsuhama Corporation, that I am carrying over from the setting, but the assumption is that most of the material will come from the players.
Venture City exists in a dystopian near-future where supers are a known part of the world. The flavor of the setting is cyberpunk, which we can focus on or not.